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KMID : 1812020140200010064
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Journal of Neurogastroenterology and Motility
2014 Volume.20 No. 1 p.64 ~ p.73
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Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks oRelief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Groupf Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group
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Abstract
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Background/Aims: To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and ex-tra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms.
Methods: Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the pa-tient-completed ReQuest in PracticeTM questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms.
Results: Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P ＜ 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks im-proved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduc-tion on ReQuest in PracticeTM dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated.
Conclusions: Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms in-cluding sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.
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KEYWORD
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Gastroesophageal, Night-time symptoms, Pantoprazole, Proton pump inhibitors
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